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Effect of Interferon B-1b in MS, Assessment of Annual Accumulation of PD/T2 Activity on MRI Neurol 54:200-206, Zhao,G.J.,et al, 2000 See this aricle in Pubmed Article Abstract During the 5 years, both high- and low-dose IFNbeta-1b groups showed a striking reduction in lesion annual accumulation activity on the activity index versus placebo (p = 0.001). Thirty-five percent of the high-dose patients and 29% of th e low-dose patients were MRI inactive by this method of analysis, whereas only 16% of placebo patients were inactive (p = 0.001, placebo versus 8 mIU). This analysis of the annual accumulation of lesion activity shows that the previously reported treatme nt effect seen on MRI scanning once every 6 weeks in a subcohort of the patients can also be seen on yearly scans. This annual accumulation activity analysis provides an independent MRI confirmation of a treatment and dose effect for IFNbeta-1b.

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(click to filter results - removes previous filter) interferon beta 1-b MRI MRI,abnormal multiple sclerosis multiple sclerosis,treatment of treatment of neurologic disorder

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